- 涓婃捣淇濆湥闆诲瓙榧籧Nose锛氭灣娈煎搧璩ⅷ鍛崇爺绌剁殑闂滈嵉鍔╁姏
- 鐧�(f膩)甯冩棩鏈燂細2025-03-20 鐎忚娆℃暩(sh霉)锛�179
涓�銆佺爺绌惰儗鏅�
鏋虫锛�Fructus Aurantii锛�FA锛変綔鐐鸿棩椋熷叐鐢ㄧ殑鍔熻兘鎬ч鍝�锛屽湪淇冮�叉秷鍖栨柟闈㈠姛鏁堥’钁�銆傜劧鑰�锛岀敓鏋虫锛�RFA锛夊皪閮ㄥ垎鎮ｈ�呭瓨鍦ㄥ壇浣滅敤锛屽洜姝よ嚚搴婂浣跨敤鐐埗鍚庣殑鏋虫锛�PFA锛�銆傜洰鍓�锛�FA鐨勭敓鐢㈠拰璩噺瑭曞児涓昏渚濊炒鍌崇当(t菕ng)鏂规硶锛岄�欑ó鏂瑰紡涓昏鎬у挤锛屽皫鑷寸敘鍝佽唱閲忕┅(w臎n)瀹氭�у樊銆傚缓绔嬪瑙�銆佸叏闈㈢殑PFA璩噺瑭曞児楂旂郴杩湪鐪夌潾銆�
FA鐨勯ⅷ鍛虫槸鍏跺搧璩殑闂滈嵉鎸囨涔嬩竴锛岀洿鎺ュ奖闊跨敘鍝佺殑鎳夌敤鍜屾秷璨昏�呮帴鍙楀害銆傚叾棰ㄥ懗璁婂寲鑸囨彯鐧�(f膩)鎬ф垚鍒嗗瘑鍒囩浉闂�锛岃�岄浕瀛愰蓟浣滅偤涓�绋ā鎿汉椤炲梾瑕虹郴绲�(t菕ng)鐨勬櫤鑳芥娓ō鍌�锛岃兘澶犲揩閫熴�佷綆鎴愭湰鍦扮嵅鍙栨埃鍛充俊鎭�锛屽湪椋熷搧鍜岄啱(y墨)钘ョ敓鐢㈢殑閬庣▼鐩�(ji膩n)鎺ц垏璩噺鎺у埗闋樺煙鎳夌敤寤ｆ硾銆傚湪FA鐨勭爺绌朵腑锛岄浕瀛愰蓟鍙敤浜庡垎鏋愬叾鎻櫦(f膩)鎬ф垚鍒嗚畩鍖�锛岀偤鍝佽唱瑭曞児鎻愪緵閲嶈渚濇摎(j霉)銆傚悓鏅�锛岀祼鍚堢浉灏嶆埃鍛虫椿鎬у�硷紙ROAV锛夌瓑鍒嗘瀽鏂规硶锛岃兘鏇村叏闈��佸瑙�鍦板弽鏄�FA鍔犲伐鍚庢彯鐧�(f膩)鎬чⅷ鍛冲寲鍚堢墿鐨勮畩鍖栫壒寰�锛屽皪蹇�熻唱閲忚⿻鍍规剰缇╅噸澶с��
浜�銆佸椹楁柟娉�
锛堜竴锛夋ǎ鍝佹簴鍌�
瀵﹂鎵�鐢ㄧ殑RFA鍜�PFA鍧囬噰璩艰嚜寤ｅ窞瀛愬閱�(y墨)钘ュ仴搴锋湁闄愬叕鍙�锛屽苟缍撳唬宸炰腑閱�(y墨)钘ュぇ瀛稿嫉涓圭嚂鏁欐巿閼掑畾銆�RFA鍦�7鏈堥噰鎽�锛岀稉骞茬嚗銆佸垏鐗囩瓑铏曠悊锛�PFA鍓囨槸鍦�RFA鍩虹涓�锛岀稉閬庣櫦(f膩)閰�銆佹竻娲�銆佽捀鍒剁瓑涓�绯诲垪鍔犲伐宸ュ簭鍒舵垚銆�
锛堜簩锛�涓婃捣淇濆湥闆诲瓙榧�cNose妾㈡脯
閲囩敤涓婃捣淇濆湥瀵︽キ(y猫)鐧�(f膩)灞曟湁闄愬叕鍙哥敓鐢㈢殑闆诲瓙榧诲皪RFA鍜�PFA閫茶妾㈡脯銆傝┎闆诲瓙榧婚厤鍌�18绋笉鍚岀殑閲戝爆姘у寲鐗╁崐灏庨珨锛�MOS锛夊偝鎰熷櫒锛屽彲妾㈡脯澶氱ó鎻櫦(f膩)鎬х墿璩�傚椹楁檪锛岀簿纰虹ū鍙�4.0g妯ｅ搧锛屾斁鍏�20mL闋傜┖鐜荤拑瀵岄泦鐡朵腑锛屽瘑灏佸悗鍦�26鈩冪挵(hu谩n)澧冧笅闈滅疆30min銆傝ō缃浕瀛愰蓟鐨勬竻娼旀檪闁撶偤120s锛岃級姘ｆ祦閲忕偤400mL/min锛屽湪60s鍏ц閷�18鍊嬪偝鎰熷櫒鐨勯熆鎳夊��锛屼互鐢熸垚闊挎噳鏇茬窔銆傞伕鍙栧悇鎴愬垎鐨勬渶澶ч熆鎳夊�奸�茶鏁�(sh霉)鎿�(j霉)鍒嗘瀽锛屽緸鏁撮珨涓婅⿻浼版ǎ鍝佺殑鎻櫦(f膩)鎬х壒寰�銆�
锛堜笁锛夋暩(sh霉)鎿�(j霉)铏曠悊
閬嬬敤GraphPad Prism 8杌熶欢閫茶鏁�(sh霉)鎿�(j霉)绲�(t菕ng)瑷堝垎鏋愶紝閫氶亷鍠洜绱犳柟宸垎鏋愶紙ANOVA锛夋瘮杓冧笉鍚岀祫鏁�(sh霉)鎿�(j霉)鐨勫樊鐣�锛岀⒑瀹氬椹楃祼鏋滅殑椤憲鎬�銆傚埄鐢�Origin 2021杌熶欢灏嶉浕瀛愰蓟鏁�(sh霉)鎿�(j霉)閫茶涓绘垚鍒嗗垎鏋愶紙PCA锛�锛岀洿瑙�鍛堢従(xi脿n)涓嶅悓妯ｅ搧闁撶殑宸暟鍜岀浉浼兼�э紝浠ユ帰绱㈡暩(sh霉)鎿�(j霉)鐨勬經鍦ㄧ祼妲�銆傚�熷姪SIMCA 14.1杌熶欢閫茶姝ｄ氦鍋忔渶灏忎簩涔樻硶鍒ゅ垾鍒嗘瀽锛�OPLS - DA锛夛紝閫蹭竴姝ユ寲鎺樻暩(sh霉)鎿�(j霉)涓殑闂滈嵉淇℃伅锛屽皨鎵惧崁(q奴)鍒�RFA鍜�PFA鐨勯棞閸垫瑷樼墿锛屽苟瑭曚及妯″瀷鐨勬摤鍚堝劒(y艒u)搴﹀拰闋愭脯鑳藉姏銆�
涓夈�佸椹楃祼鏋�
锛堜竴锛夐浕瀛愰蓟鍗�(q奴)鍒嗘晥鏋�
閫氶亷灞ゆ鑱氶鍒嗘瀽锛�HCA锛夊皪闆诲瓙榧荤殑鏈�澶ч熆鎳夊�奸�茶鍒嗘瀽锛岀祼鏋滈’绀烘墍鏈夋ǎ鍝佸彲鍒嗙偤鍏╁ぇ椤�锛岃〃鏄�RFA鍜�PFA鍦ㄦ埃鍛崇壒寰佷笂瀛樺湪鏄庨’宸暟銆備富鎴愬垎鍒嗘瀽锛�PCA锛夌殑寰楀垎鍦栦腑锛�PC1鍜�PC2鍒嗗垾瑙ｉ噵浜�64.4%鍜�26.1%鐨勬柟宸紝鐩＄妯ｅ搧榛炲瓨鍦ㄩ儴鍒嗛噸鐤�锛屼絾浠嶈兘瑙�瀵熷埌涓嶅悓鍝佺ó闁撶殑鍒嗛洟瓒ㄥ嫝銆�
閫蹭竴姝ョ殑姝ｄ氦鍋忔渶灏忎簩涔樻硶鍒ゅ垾鍒嗘瀽锛�OPLS - DA锛夊緱鍒嗗湒娓呮櫚鍦板睍绀轰簡鍏╃祫妯ｅ搧鐨勫樊鐣�锛岀崹绔嬭畩閲忔摤鍚堟寚鏁�(sh霉)锛�\(R^{2}X\)锛夌偤0.947锛屽洜璁婇噺鎿悎鎸囨暩(sh霉)锛�\(R^{2}Y\)锛夌偤0.965锛岄爯娓晥鐜囷紙\(Q^{2}\)锛夐仈鍒�0.944锛岄璀夊弮鏁�(sh霉)\(R^{2}\)鍜�\(Q^{2}\)鍧囪秴閬�0.5锛岃〃鏄庢ā鍨嬫摤鍚堣壇濂姐��RFA鍜�PFA鍒嗗垾鍧囧嫽鍒嗗竷鍦ㄦ按骞宠桓鐨勮矤鍗婅桓鍜屾鍗婅桓锛岃鏄庝笉鍚屾ǎ鍝佺殑閲嶅京鎬ц壇濂斤紝涓斾簩鑰呭湪棣欐埃涓婂瓨鍦ㄩ’钁楀樊鐣�銆�
锛堜簩锛夐棞閸靛偝鎰熷櫒纰哄畾
绲愬悎闆烽仈鍦栧垎鏋愮櫦(f膩)鐝�(xi脿n)锛岄浕瀛愰蓟鍙�氶亷sensor4銆�sensor5銆�sensor14銆�sensor17鍜�sensor18鍗�(q奴)鍒�PFA妯ｅ搧锛�sensor3銆�sensor6銆�sensor14鍜�sensor16灏嶆ǎ鍝佺殑棣欐埃鍖栧悎鐗╅熆鎳夎純寮�銆傞�欐剰鍛宠憲PFA涓彲鑳藉惈鏈夋洿楂樿睈搴︾殑纭寲鐗┿�佸惈姘墿璩�銆侀啗閰銆侀唶椤炲拰鐢茬兎绛夋彯鐧�(f膩)鎬у寲鍚堢墿锛屽厖鍒嗗睍绀轰簡闆诲瓙榧诲湪妾㈡脯FA鍔犲伐閬庣▼涓彯鐧�(f膩)鎬у寲鍚堢墿璁婂寲鏂归潰鐨勬晱鎰熸�у拰鏈夋晥鎬�銆�
锛堜笁锛夎垏鍏朵粬鍒嗘瀽鏂规硶鐨勯棞鑱�(li谩n)
閫氶亷灏嶉浕瀛愰蓟鏁�(sh霉)鎿�(j霉)鑸�GC - MS鍒嗘瀽绲愭灉閫茶鐩搁棞鎬у垎鏋�锛岀櫦(f膩)鐝�(xi脿n)钀滃搧鐑� - 4 - 閱�銆�6 - 琛� - 鏉炬补閱囥�佽姵妯熼唶銆佹獪鐑��α - 鐢插熀鍜�α - 鏉炬补閱囪垏涓婅堪鍌虫劅鍣ㄧ殑闊挎噳鍊煎憟璨犵浉闂�锛涜��D - 妾告鐑�銆�α - 钂庣儻銆�γ - 钀滃搧鐑拰鐠�(hu谩n)宸辩兎鐢查唶鐨勮睈搴﹁垏sensor3銆�sensor4銆�sensor5銆�sensor6銆�sensor14銆�sensor16銆�sensor17鍜�sensor18鐨勪俊铏熷挤搴﹀憟寮锋鐩搁棞銆傞�欒〃鏄庨浕瀛愰蓟鑳藉灏�FA涓壒瀹氱殑鎻櫦(f膩)鎬у寲鍚堢墿鍋氬嚭闊挎噳锛岃垏GC - MS鍒嗘瀽绲愭灉鐩镐簰鍗拌瓑锛岄�蹭竴姝ラ璀変簡闆诲瓙榧绘暩(sh霉)鎿�(j霉)鐨勫彲闈犳��锛屼篃楂旂従(xi脿n)浜嗗叾鍦ㄥ垽鏂�FA鐢㈠搧棰ㄥ懗鏂归潰鐨勯噸瑕佷綔鐢�銆�
鍦ㄦ灣娈煎搧璩⿻鍍圭爺绌朵腑锛岄浕瀛愰蓟鐧�(f膩)鎻簡鑷抽棞閲嶈鐨勪綔鐢�銆傚畠鑳藉鏈夋晥鍗�(q奴)鍒�RFA鍜�PFA鐨勯姘ｇ壒寰�锛岀⒑瀹氶棞閸靛偝鎰熷櫒锛屽苟涓旇垏鍏朵粬鍒嗘瀽鏂规硶鐩镐簰闂滆伅(li谩n)锛岀偤鍏ㄩ潰浜嗚В鏋虫鍦ㄥ姞宸ラ亷绋嬩腑鐨勯ⅷ鍛宠畩鍖栨彁渚涗簡鏈夊姏鏀寔锛屽皪寤虹珛绉戝鐨勬灣娈艰唱閲忚⿻鍍归珨绯诲叿鏈夐噸瑕佹剰缇�銆�
- 涓婁竴绡囷細璩鍒嗘瀽鍎�锛圱A- 璩鍒嗘瀽鍎�锛圱A-XTC-20锛夛細鍙ｈ厰璨肩墖鐮旂┒鐨勯棞閸靛姪鍔�
- 涓嬩竴绡囷細淇濆湥闆诲瓙榧籧Nose 鍦ㄦ灉閰掗ⅷ鍛冲垎鏋愪腑鐨勬噳鐢ㄧ爺绌�
琛屾キ(y猫)璩囪▕鎵�鍦ㄤ綅缃細棣栭爜 >> 琛屾キ(y猫)璩囪▕ >> 涓婃捣淇濆湥闆诲瓙榧籧Nose锛氭灣娈煎搧璩ⅷ鍛崇爺绌剁殑闂滈嵉鍔╁姏
